A focused series of substituted 4H-1. 2. 6-thiadiazin-4-ones was designed and synthesized to probe the anti-cancer properties of this scaffold. Insights from previous kinase inhibitor programs were used to carefully select several different substitution patterns. https://www.nacrack.com/amazing-price-1997-2000-BMW-528I-Front-Bumper-Reinforcement-Bar-Used-Original-Exterior-OEM-great-save/